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The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy

Joanna Szostak1, Anna Gorący1, Damian Durys1

  • 1Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.

International Journal of Molecular Sciences
|April 13, 2023
PubMed

Insights

Diabetic nephropathy, a severe diabetes complication, involves complex pathways. MicroRNAs (miRNAs) are increasingly recognized as key regulators and potential biomarkers for this condition.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic nephropathy is a major complication of diabetes mellitus, affecting 20% of patients.
  • The precise mechanisms driving diabetic nephropathy remain incompletely understood.
  • Known contributing factors include oxidative stress and the renin-angiotensin-aldosterone system, potentially regulated by microRNAs.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in diabetic nephropathy pathogenesis.
  • To explore the clinical potential of miRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review focusing on microRNA involvement in diabetic nephropathy pathways.
  • Analysis of current research on miRNA expression profiles in diabetic nephropathy patients.
  • Examination of studies investigating miRNA-based diagnostics and therapeutics.

Main Results:

  • MicroRNA expression profiles are significantly altered in patients with diabetic nephropathy.
  • miRNAs play a crucial role in regulating pathways implicated in disease development.
  • Emerging evidence supports the use of miRNAs as diagnostic and therapeutic tools.

Conclusions:

  • MicroRNAs are critical players in the pathogenesis of diabetic nephropathy.
  • Targeting miRNAs offers promising avenues for future clinical applications in managing diabetic kidney disease.
Keywords:
biomarkersdiabetes mellitusdiabetic nephropathymicroRNAoxidative stresstransforming growth factor beta

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