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Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease-A Translational Perspective

Aydin Huseynov1, Julius Reinhardt1, Leonard Chandra1

  • 1Department of Medicine, Cardiology, Angiology, Hemostasis and Intensive Care Medicine, University Medical Center Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, 68135 Mannheim, Germany.

International Journal of Molecular Sciences
|April 13, 2023
PubMed

Insights

Platelets are key in cardiovascular disease, influencing thrombosis and inflammation. This review explores platelet functions, anti-platelet drugs, and their role in atherosclerosis and regenerative medicine.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pharmacology

Background:

  • Platelets are crucial cellular components in cardiovascular disease pathogenesis.
  • Current understanding highlights platelets' roles beyond thrombosis, including inflammation and tissue repair.
  • Translational and clinical insights are essential for developing effective anti-platelet therapies.

Purpose of the Study:

  • To review the multifaceted functions and interactions of platelets.
  • To discuss the role of platelets in atherosclerosis development and prevention.
  • To explore novel anti-platelet therapies and regenerative medicine applications.

Main Methods:

  • Comprehensive literature review of basic science, translational, and clinical studies.
  • Analysis of platelet functions in vascular inflammation, remodeling, and healing.
  • Evaluation of therapeutic strategies for primary and secondary prevention of atherosclerotic disease.

Main Results:

  • Established anti-platelet drug regimens are vital for cardiovascular patients.
  • Platelets significantly contribute to atherosclerosis progression.
  • Novel therapeutic approaches targeting platelet function show promise.

Conclusions:

  • Platelet-targeted therapies are central to managing cardiovascular diseases.
  • Understanding platelet interactions is key for developing advanced treatments.
  • Platelets hold potential in regenerative medicine strategies.

Keywords:
atherosclerosiscoronary artery diseaseischemic strokemyocardial infarctionneuroinflammationneurovascular diseaseplateletsthrombosis

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