Related Experiment Video

Updated: Aug 3, 2025

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.1K

The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression

Alexander M Markin1,2, Yuliya V Markina1, Anastasia I Bogatyreva1

  • 1Petrovsky National Research Center of Surgery, 119991 Moscow, Russia.

International Journal of Molecular Sciences
|April 13, 2023
PubMed

Insights

Atherosclerosis, a leading cause of death, involves chronic inflammation and immune cells. This review summarizes key cytokines, such as interferons and interleukins, crucial in atherogenesis.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Inflammation Research

Background:

  • Atherosclerosis is a primary global cause of mortality, characterized by chronic inflammation and autoimmune aspects.
  • It involves cholesterol accumulation in vessel walls, leading to atherosclerotic plaque formation and endothelial dysfunction.

Purpose of the Study:

  • To review and summarize the critical roles of cytokines in the development of atherosclerosis (atherogenesis).

Main Methods:

  • Literature review synthesizing current research on immune cell involvement in atherogenesis.
  • Focus on the production and activation of cytokines by immune cells like monocytes and macrophages.

Main Results:

  • Immune cells, including monocytes and macrophages, are integral to atherogenesis.
  • These cells produce and activate various cytokines, such as interferons, interleukins, and chemokines, driving the inflammatory process.

Conclusions:

  • Cytokines play a pivotal role in the complex inflammatory pathways of atherosclerosis.
  • Understanding these cytokine-mediated processes is essential for developing targeted therapies for cardiovascular disease.

Keywords:
atherosclerosischolesterol accumulationcytokinesinflammation

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.2K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
20
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
613
Inflammation01:38

Inflammation

Overview
54.1K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
18
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
39