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Isolation of Functional Cardiac Immune Cells
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Pathophysiological Effects of Various Interleukins on Primary Cell Types in Common Heart Disease

Yong Liu1,2, Donghui Zhang1,2, Dan Yin1,2

  • 1State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan 430062, China.

International Journal of Molecular Sciences
|April 13, 2023
PubMed

Insights

This review explores how interleukins impact heart disease by affecting specific heart cells. Understanding these interleukin pathways could lead to more targeted and effective heart disease therapies.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Cellular Pathophysiology

Background:

  • Common heart diseases like myocardial infarction and heart failure lack effective therapies due to complex pathogenesis.
  • Cardiomyocytes, fibroblasts, endothelial cells, and immune cells are key players in heart disorders.
  • The specific roles of interleukins and their pathways in these primary heart cells are not well understood.

Purpose of the Study:

  • To review the pathophysiological effects of various interleukins on primary cell types in common heart diseases.
  • To elucidate the complex roles of interleukins in cardiovascular disease.
  • To provide insights for developing more precise and effective heart disease treatments.

Main Methods:

  • Literature review focusing on interleukins and their effects on cardiomyocytes, fibroblasts, endothelial cells, and immune cells.
  • Analysis of pathophysiological pathways involving specific interleukins in heart disease models.
  • Synthesis of current knowledge on interleukin functions in cardiovascular contexts.

Main Results:

  • Interleukins, including the IL-1 family, IL-2, IL-4, IL-6 family, IL-8, IL-10, and IL-17, exhibit diverse effects on different cardiac cell types.
  • Specific interleukin actions can promote or inhibit disease progression depending on the cell type and context.
  • The complex interplay between interleukins and cardiac cells contributes significantly to heart disease pathogenesis.

Conclusions:

  • Targeting specific cell types with tailored interleukin-modulating therapies holds promise for treating heart disease.
  • Further research into interleukin-specific cellular mechanisms is crucial for advancing cardiovascular medicine.
  • A deeper understanding of these pathways can lead to novel therapeutic strategies for myocardial infarction, heart failure, and other cardiac conditions.

Keywords:
cardiomyocytesfibroblastsheart diseaseimmune cellsinterleukin

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