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Sevoflurane Induces a Cyclophilin D-Dependent Decrease of Neural Progenitor Cells Migration.

Pan Lu1,2, Feng Liang2, Yuanlin Dong2

  • 1Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

International Journal of Molecular Sciences
|April 13, 2023
PubMed
Summary
This summary is machine-generated.

Sevoflurane anesthesia impairs neural progenitor cell migration in young animals by increasing cyclophilin D (CypD) and reactive oxygen species (ROS). Deleting CypD protected against these sevoflurane-induced effects, highlighting CypD

Keywords:
cyclophilin Ddoublecortinmigrationneural progenitor cellssevoflurane

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Area of Science:

  • Neuroscience
  • Anesthesiology
  • Developmental Biology

Background:

  • Repeated exposure to anesthesia in early life may lead to cognitive impairment.
  • Sevoflurane affects neurogenesis and cognitive function by altering mitochondrial function and cyclophilin D (CypD) levels.
  • Neural progenitor cell (NPC) migration is crucial for cognitive development, but its regulation by sevoflurane via CypD is unknown.

Purpose of the Study:

  • To investigate whether sevoflurane regulates neural progenitor cell (NPC) migration through alterations in cyclophilin D (CypD).
  • To determine the role of CypD in sevoflurane-induced effects on NPC migration and associated molecular changes.

Main Methods:

  • Neural progenitor cells (NPCs) and young mice from wild-type (WT) and CypD knockout (KO) models were exposed to sevoflurane.
  • Immunofluorescence staining, wound healing assays, Transwell assays, mass spectrometry, and Western blot analyses were employed.
  • Levels of CypD, reactive oxygen species (ROS), and doublecortin were assessed, alongside NPC migration.

Main Results:

  • Sevoflurane exposure increased CypD and ROS levels while decreasing doublecortin and NPC migration in WT mice.
  • These sevoflurane-induced impairments were significantly attenuated in CypD knockout (KO) mice.
  • The results indicate that sevoflurane's negative impact on NPC migration is dependent on the presence of CypD.

Conclusions:

  • Sevoflurane anesthesia impairs neural progenitor cell (NPC) migration in a CypD-dependent manner.
  • This study establishes a mechanistic link between sevoflurane exposure, CypD, and impaired NPC migration.
  • Findings provide a foundation for further research into anesthesia-related cognitive risks in developing brains.