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Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

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Published on: January 12, 2020

High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy.

Bram DeWulf¹, Laurens Minsart², Franck Verdonk³

¹Department of Anesthesia-Critical Care, AZ Sint-Jan Brugge Oostende AV, 8000 Bruges, Belgium.

|April 13, 2023

Summary

This summary is machine-generated.

Sepsis-associated encephalopathy (SAE) lacks diagnostic tools. Targeting high mobility group box 1 (HMGB1) may mitigate neuroinflammation and complement current sepsis-induced encephalopathy treatments.

Keywords:

HMGB1 high mobility group box 1 sepsis sepsis-associated encephalopathy

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Area of Science:

Critical Care Medicine
Neuroscience
Immunology

Background:

Sepsis-associated encephalopathy (SAE) presents diagnostic and definition challenges for intensivists.
Risk factors include age, genetics, and pre-existing neuropsychiatric conditions, with certain infections posing higher risks.
Current intensive care unit (ICU) management relies on non-pharmacological support.

Purpose of the Study:

To review the role of high mobility group box 1 (HMGB1) in SAE pathogenesis.
To explore HMGB1-targeted strategies for mitigating sepsis-induced neuroinflammation.
To discuss HMGB1 as a potential therapeutic target for SAE.

Main Methods:

Review of pre-clinical studies on HMGB1 in sepsis and neurological disorders.
Analysis of HMGB1's role in neuroinflammation and blood-brain barrier disruption.
Examination of inflammatory cascades involving HMGB1.

Main Results:

HMGB1, an alarmin, is implicated in the pathogenesis of SAE.
Extracellular HMGB1 translocation triggers neuroinflammatory reactions and compromises the blood-brain barrier.
Targeting HMGB1 may inhibit inflammatory cascades.

Conclusions:

HMGB1 plays a significant role in neuroinflammation following sepsis.
Inhibiting HMGB1-mediated inflammation offers a potential therapeutic strategy for SAE.
Targeting HMGB1 could complement existing non-pharmacological interventions for SAE.