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Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review
Sofia D Shaikh1, Natalie Sun1, Andrew Canakis2
1Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Journal of Clinical Medicine
|April 13, 2023
Summary
Irritable Bowel Syndrome (IBS) is a common gut disorder impacting quality of life. This review explores how gut microbiota influences IBS and its potential as a treatment target.
Area of Science:
- Gastroenterology
- Microbiology
- Neurogastroenterology
Background:
- Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder.
- IBS significantly impacts quality of life, work productivity, and healthcare costs.
- The pathophysiology involves brain-gut axis dysregulation and altered gut microbiota.
Purpose of the Study:
- To review the role of gut microbiota in IBS pathophysiology.
- To identify factors influencing the gut microbiome in IBS.
- To explore the gut microbiome as a therapeutic target for IBS.
Main Methods:
- Literature review of studies on IBS and gut microbiota.
- Analysis of factors affecting gut microbiome composition.
- Evaluation of microbiome-targeted therapies for IBS.
Main Results:
- Gut microbiota alterations are implicated in IBS development and symptoms.
- Factors like diet, antibiotics, and stress impact the gut microbiome in IBS.
- Emerging evidence supports microbiome modulation as a viable IBS treatment strategy.
Conclusions:
- The gut microbiota plays a crucial role in IBS pathophysiology.
- Understanding microbiome dynamics is key to developing effective IBS treatments.
- Targeting the gut microbiome offers promising therapeutic avenues for IBS management.
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