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Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year

Roberta Rossi1, Stefania Benetti2, Barbara Lauria1

  • 1Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children's Hospital, A.O.U. Città della Salute e della Scienza di Torino, Piazza Polonia 94, 10126 Turin, Italy.

Journal of Clinical Medicine
|April 13, 2023
PubMed

Insights

Children with a family history of stroke or deep vein thrombosis (DVT) have an increased risk of developing migraine with aura (MA). This finding highlights a potential link between thrombotic predisposition and childhood migraine.

Area of Science:

  • Neurology
  • Pediatrics
  • Cardiovascular Medicine

Background:

  • Migraine is a common primary headache disorder in children.
  • The connection between thrombotic predisposition and migraine pathogenesis in pediatric populations remains under investigation.
  • This study examines cardiovascular risk factors and family history of thrombotic events in children diagnosed with migraine.

Purpose of the Study:

  • To investigate the association between family history of major thrombotic events and childhood migraine.
  • To analyze cardiovascular risk factors in pediatric migraine patients.
  • To compare children with migraine with a control group of healthy children.

Main Methods:

  • A retrospective, single-center study spanning 12 years.
  • Database screening for migraine with aura (MA) and migraine without aura (MO) based on ICHD criteria.
  • Inclusion of a control group of healthy children for comparison; statistical analyses performed with significance set at p < 0.05.

Main Results:

  • Out of 930 children diagnosed with migraine, 24.7% had MA, and 73.3% were aged 9-14 years.
  • Children with MA had a significantly higher prevalence of family history of cerebral ischemic events (≤50 years) compared to those with MO and controls (p < 0.001).
  • A family history of deep vein thrombosis (DVT) showed a significantly increased risk for MA compared to MO (OR: 2.9).

Conclusions:

  • A family history of cerebral ischemic events occurring at or before age 50 is associated with an increased risk of developing migraine with aura (MA) in children.
  • The findings suggest a potential genetic link or shared risk factors between thrombotic events and MA.
  • Further research is warranted to elucidate the specific mechanisms underlying this association.
Abstract

Keywords:
International Classification of Headache Disorders, third edition (ICHD-III)cardiovascular eventschildrenmigraine

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