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Updated: Aug 3, 2025

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic
Enav Yefet1,2, Liron Bar1, Ido Izhaki3
1Department of Obstetrics and Gynecology, Tzafon Medical Center, Poriya 1528001, Israel.
Objectives:
To assess the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM) by performing a systematic review and meta-analysis of randomized controlled trials. The primary outcome was glycemic control, i.e., serum glucose and insulin levels. Secondary outcomes were maternal weight gain, neonatal birth weight, and lipid parameters. Weighted mean difference (WMD) was used. Cochrane's Q test of heterogeneity and I2 were used to assess heterogeneity.
Results:
Of the 843 papers retrieved, 14 (n = 854 women) met the inclusion criteria and were analyzed. When compared with placebo, women receiving probiotic supplements had significantly lower mean fasting serum glucose, fasting serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, and VLDL levels. Decreased neonatal birth weight was witnessed in supplements containing Lactobacillus acidophilus.
Conclusion:
Probiotic supplements may improve glycemic control and lipid profile and reduce neonatal birth weight in women with GDM.
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