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Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities
Yanjun Sun1,2,3, Haojie Wang1,2, Ruijie Han1,2
1Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Abstract:
One new dibenzyltyrolactone lignan dysoslignan A (1), three new arylnaphthalide lignans dysoslignan B-C (2-4), along with fourteen known metabolites (5-18), were isolated from the roots and rhizomes of Dysosma versipellis. Their structures and stereochemistry were determined from analysis of NMR spectroscopic and circular dichroism (CD) data. Compound 2 represents the first report of naturally occurring arylnaphthalide lignan triglycoside. The cytotoxic activities of all isolated compounds were evaluated against A-549 and SMMC-7721 cell lines. Compounds 7-10 and 14-16 were more toxic than cisplatin in two tumor cell lines. This investigation clarifies the potential effective substance basis of D. versipellis in tumor treatment.
