Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Modified-Release Drug Delivery Systems: Bioavailability

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A supramolecular assembly of a disulfide-linked adamantane-curcumin conjugate and amphiphilic cyclodextrin with redox-responsive potential.

Organic & biomolecular chemistry·2026

Same author

Ligand-mediated formation of amphiphilic silver nanoclusters: synthesis, redox properties, and activity against clinically relevant bacteria.

Journal of materials chemistry. B·2026

Same author

Graphene Dot-ZnO Hybrid Nanostructures as High-Performance Chemiresistive Sensors for H<sub>2</sub>S Detection.

ACS omega·2026

Same author

Halogen-Containing Drugs in 2025: A Record Year for the Therapeutic Use and Synthesis of FDA-Approved Small Molecules.

Biomolecules·2026

Same author

Stereospecificity Membrane Impact of Two Catechins on Red Blood Cells.

Antioxidants (Basel, Switzerland)·2026

Same author

PEG-β-Cyclodextrin polymer-based formulation to increase the antiangiogenic activity of rutin in vivo.

International journal of pharmaceutics·2026

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study.

Federica De Gaetano¹, Angela Scala¹, Consuelo Celesti^2,3

¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

Molecules (Basel, Switzerland)

|April 13, 2023

Summary

This study developed novel nanoparticles using octanoyl-β-cyclodextrin to improve idebenone delivery for neurological disorders. The nanoparticles effectively loaded idebenone, showed sustained release, and demonstrated antioxidant properties without toxicity.

Keywords:

NMR studies amphiphilic cyclodextrins idebenone in vitro antioxidant activity molecular modeling nanoparticles

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Area of Science:

Nanomedicine
Neuropharmacology
Supramolecular Chemistry

Background:

Idebenone (IDE) is a potent antioxidant with therapeutic potential for cerebral disorders.
Poor water solubility of IDE limits its clinical application.
Octanoyl-β-cyclodextrin (ACyD8) forms supramolecular nanoassemblies suitable for drug delivery.

Purpose of the Study:

To develop ACyD8-based nanoparticles (ACyD8-NPs) for intranasal administration of IDE.
To enhance IDE's delivery for treating neurological disorders like Alzheimer's Disease.
To characterize the IDE/ACyD8 interaction and IDE release profile.

Main Methods:

Nanoparticle preparation via nanoprecipitation.
Characterization of size, zeta potential, and morphology (STEM).
Evaluation of host/guest interaction (UV-vis, NMR, molecular modeling) and drug release kinetics.

Main Results:

ACyD8-NPs were spherical, ~100 nm in size, suitable for intranasal delivery.
High encapsulation efficiency and drug loading of IDE.
IDE formed a 1:1 inclusion complex with ACyD8, exhibiting high affinity.
Sustained, biphasic IDE release over 10 days after an initial burst.
IDE/ACyD8-NPs showed no toxicity to SH-SY5Y cells and exhibited antioxidant activity.

Conclusions:

ACyD8-NPs are a promising nanocarrier for intranasal delivery of IDE.
This formulation overcomes IDE's solubility limitations for potential neurological disorder treatment.
The developed nanoparticles demonstrate safety and efficacy in vitro, supporting further investigation.