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Histamine challenge testing: comparison of three methods.

J Britton, A Mortagy, A Tattersfield

    Thorax
    |February 1, 1986
    PubMed
    Summary
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    Two simpler histamine challenge tests for asthma, the Mortagy and Yan methods, are viable alternatives to the Cockcroft method for epidemiological studies. The Yan technique offers the greatest advantages due to its speed and ease of use.

    Area of Science:

    • Pulmonology
    • Clinical Medicine
    • Epidemiology

    Background:

    • Non-specific bronchial reactivity correlates with asthma severity.
    • Histamine challenge testing is crucial for epidemiological studies on asthma prevalence and morbidity.
    • The standard Cockcroft method, while reliable, is slow and requires specialized equipment for large-scale studies.

    Purpose of the Study:

    • To evaluate the efficacy and practicality of two alternative histamine challenge methods (Yan and Mortagy) compared to the established Cockcroft method.
    • To determine the suitability of these simpler methods for epidemiological research on asthma.

    Main Methods:

    • A balanced design study involving 24 adult asthma patients.
    • Comparison of three histamine challenge methods: Cockcroft, Yan, and Mortagy.

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  • Assessment of method repeatability and time efficiency.

    • Main Results:

    • The Mortagy and Yan methods successfully recorded results in all 24 subjects, unlike the Cockcroft method (16 subjects).
    • Repeatability was similar across all methods, with 95% ranges of +/- 1.94, 2.11, and 2.40 doubling concentrations for Mortagy, Yan, and Cockcroft, respectively.
    • The Mortagy and Yan methods were significantly faster (under 15 minutes) and required less cumbersome equipment than the Cockcroft method (up to 45 minutes).

    Conclusions:

    • The Mortagy and Yan histamine challenge methods demonstrate similar repeatability to the Cockcroft method.
    • These faster, simpler techniques are practical alternatives for epidemiological studies of asthma.
    • The Yan technique is recommended for epidemiological studies due to its efficiency and ease of standardization, overcoming technical issues associated with the Mortagy method.