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Related Experiment Videos

Long lasting sitting position and haemostasis.

P E Makris, C Louizou, C Markakis

    Thrombosis and Haemostasis
    |February 28, 1986
    PubMed
    Summary
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    Long car journeys significantly alter blood coagulation and platelet activity. Aspirin administration partially mitigated these effects, suggesting its potential role in managing travel-related hemostatic changes.

    Area of Science:

    • Physiology
    • Hematology
    • Travel Medicine

    Background:

    • Prolonged sitting during travel can impact hemostatic balance.
    • Understanding these physiological changes is crucial for traveler health.

    Purpose of the Study:

    • To investigate the effects of long-distance car travel on blood coagulation, fibrinolysis, and platelet aggregability.
    • To assess the influence of aspirin on these travel-induced hemostatic alterations.

    Main Methods:

    • Eight physicians (30-40 years) underwent two 510 km car journeys (Salonica to Athens and return).
    • Blood parameters including platelet aggregability, antithrombin III (AT III), Factor VIII (F VIII:C / F VIIIR: Ag ratio), and euglobulin lysis time (ELT) were measured.
    • Journey B included a 48-hour rest period and 1g aspirin administration.

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    Main Results:

    • Journey A (no aspirin) showed increased platelet aggregability, decreased AT III, reduced F VIII:C / F VIIIR: Ag ratio, and prolonged ELT.
    • Journey B (with aspirin) revealed unaffected platelet aggregation, non-significant AT III decrease, and shortened ELT.
    • Both journeys resulted in a significant increase in platelet counts.

    Conclusions:

    • Long-duration sitting during car travel induces significant changes in hemostatic balance.
    • Aspirin appears to modulate some of the adverse hemostatic effects of prolonged travel.
    • Further research is warranted to explore the clinical implications of travel-related hemostatic changes.