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Related Experiment Video

Updated: Jun 7, 2026

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological

Anca Filimon¹, Mihaela Dorina Onofrei¹, Alexandra Bargan²

¹Polycondensation and Thermostable Polymers Department, "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania.

|April 13, 2023

Summary

This study introduces a new formulation embedding silver nanoparticles (AgNPs) in hydroxypropyl methyl cellulose (HPMC) using poly(N-vinylpyrrolidone) (PVP). The resulting material shows enhanced antibacterial activity, making it suitable for various biomedical applications.

Keywords:

antimicrobial activity hydroxypropyl methyl cellulose morphological characteristics poly(N-vinylpyrrolidone)silver nanoparticles

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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Area of Science:

Biomaterials Science
Nanotechnology
Materials Chemistry

Background:

Silver nanoparticles (AgNPs) exhibit significant antibacterial, antiviral, antifungal, antioxidant, and anti-inflammatory properties.
These properties make AgNPs valuable for diverse biomedical applications.
Hydroxypropyl methyl cellulose (HPMC) and poly(N-vinylpyrrolidone) (PVP) are commonly used polymers in material formulations.

Purpose of the Study:

To investigate the formulation of AgNPs embedded in HPMC using PVP as a stabilizer.
To evaluate the physicochemical properties and antimicrobial efficacy of the developed HPMC/PVP-AgNPs materials.
To assess the suitability of these materials for targeted biomedical applications.

Main Methods:

AgNPs were synthesized within HPMC solutions via thermal reduction of silver ions, with PVP acting as a stabilizer.
Characterization involved rheological measurements, spectroscopy (XRF, EDX, FTIR), diffraction (XRD), microscopy (TEM, AFM, SEM), and dynamic light scattering (DLS).
In vitro antibacterial activity was tested against *Escherichia coli* and *Staphylococcus aureus*.

Main Results:

The formulation demonstrated optimized rheological properties, with PVP playing a multifunctional role in stabilization and material property enhancement.
Characterization confirmed the formation and stability of AgNPs within the HPMC matrix.
Significant enhancement of antibacterial activity against both *E. coli* and *S. aureus* was observed with the addition of AgNPs.

Conclusions:

The developed HPMC/PVP-AgNPs material exhibits favorable characteristics for biomedical applications due to its enhanced antimicrobial properties.
The study highlights the successful integration of AgNPs into an HPMC matrix using PVP, leading to improved material performance.
This formulation presents a promising platform for developing advanced antimicrobial materials.