Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The external limiting membrane in developing normal and dysplastic canine retina.

H E Whiteley, S Young

    Tissue & Cell
    |January 1, 1986
    PubMed
    Summary

    Retinal dysplasia in English Springer Spaniels may stem from reduced gap junctions in the external limiting membrane during fetal development. This finding offers insights into canine retinal malformations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The development of comprehension and reading-related skills in children learning English as an additional language and their monolingual, English-speaking peers.

    The British journal of educational psychology·2011
    Same author

    The comprehension skills of children learning English as an additional language.

    The British journal of educational psychology·2009
    Same author

    Randomized trial of two physiotherapy interventions for primary care neck and back pain patients: 'McKenzie' vs brief physiotherapy pain management.

    Rheumatology (Oxford, England)·2006
    Same author

    The effects of male age on sperm DNA damage in healthy non-smokers.

    Human reproduction (Oxford, England)·2006
    Same author

    Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

    Proceedings of the National Academy of Sciences of the United States of America·2006
    Same author

    Major colorectal surgery in a patient with cold agglutinin disease.

    Anaesthesia·2006

    Area of Science:

    • Ophthalmology
    • Developmental Biology
    • Veterinary Medicine

    Background:

    • The external limiting membrane (ELM) is crucial for retinal development and function.
    • Retinal dysplasia is a congenital defect affecting vision in various dog breeds.

    Purpose of the Study:

    • To investigate the structural development of the ELM in normal and dysplastic canine retinas.
    • To identify potential cellular mechanisms contributing to incipient retinal dysplasia in English Springer Spaniels.

    Main Methods:

    • Transmission electron microscopy (TEM) was used to examine retinal tissue.
    • Freeze-fracture techniques were employed to visualize cell junctions within the ELM.

    Main Results:

    • Normal canine ELM contains zonulae adherentes, gap junctions, and tight junctions.
    • English Springer Spaniel fetuses with incipient retinal dysplasia showed significantly reduced gap junctions in the ELM compared to controls.
    • This reduction in gap junctions occurred concurrently with early signs of retinal dysplasia.

    Conclusions:

    • A decrease in gap junctions within the ELM may play a role in the development of retinal dysplasia in English Springer Spaniels.
    • Understanding ELM development is critical for elucidating the pathogenesis of canine retinal malformations.

    Related Experiment Videos