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Retraction

    Cancer Medicine
    |April 13, 2023
    PubMed

    Insights

    This study on papillary thyroid cancer is retracted due to confirmed image manipulation. The journal lost confidence in the findings regarding LINC00311 and cancer stem-like properties.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Context:

    • Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy.
    • Cancer stem-like cells (CSCs) are implicated in tumor recurrence and metastasis.
    • Understanding the molecular mechanisms driving CSC properties is crucial for developing effective therapies.

    Purpose:

    • To investigate the role of long non-coding RNA LINC00311 in promoting cancer stem-like properties in human papillary thyroid cancer.
    • To elucidate the underlying molecular pathway involving microRNA-330-5p (miR-330-5p) and Toll-like receptor 4 (TLR4).

    Summary:

    • The study proposed that LINC00311 enhances CSC characteristics in PTC by regulating the miR-330-5p/TLR4 axis.
    • LINC00311 was suggested to act as a competing endogenous RNA (ceRNA) for miR-330-5p, thereby upregulating TLR4 expression.
    • This interaction was hypothesized to promote stemness and potentially contribute to tumor progression.

    Impact:

    • This research aimed to identify LINC00311 as a potential therapeutic target for PTC.
    • The findings could have implications for understanding CSC biology in thyroid cancer.
    • However, the article has been retracted due to confirmed image manipulation, invalidating its conclusions.

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