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Related Experiment Videos

Plasma collection using an automated membrane device.

G Rock, P Tittley, N McCombie

    Transfusion
    |May 1, 1986
    PubMed
    Summary
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    This study evaluated a new plasmapheresis device, finding it efficiently collects plasma with high factor VIII and albumin levels. The cost-effective device showed no adverse effects on donors, making it economically viable for plasma collection.

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Clinical Apheresis

    Background:

    • Plasmapheresis is crucial for collecting plasma for transfusion and fractionation.
    • Existing devices may have limitations in efficiency, cost, or donor impact.
    • A need exists for improved, cost-effective plasmapheresis technologies.

    Purpose of the Study:

    • To evaluate the performance and safety of a novel plasmapheresis device.
    • To assess the quality of collected plasma, including key protein and cellular components.
    • To determine the economic feasibility and donor acceptance of the device.

    Main Methods:

    • A plasmapheresis device combining membrane filtration and centrifugation was tested.
    • Plasma collection efficiency (500 ml in 30 min) and anticoagulant ratio (1:12.5 ACD-A) were analyzed.

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  • Plasma quality (factor VIII, albumin, hemoglobin, cellular components) and donor effects were assessed.

    • Main Results:

    • The device collected 500 ml of plasma in 30 minutes with high factor VIII (1.05 U/ml) and albumin (41 g/L) levels.
    • No free hemoglobin, fibrinopeptide A, prekallikrein activation, or complement activation was detected.
    • Plasma had zero hematocrit and minimal platelets/white cells; donors showed no significant adverse effects.

    Conclusions:

    • The plasmapheresis device effectively collects high-quality plasma for infusion or fractionation.
    • The device demonstrates excellent safety profile for donors and minimal impact on blood components.
    • Its cost-effectiveness, with a low software cost, makes it an economically viable option for plasmapheresis.