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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
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Predicting asphyxia in term fetus.

Alev Esercan1, İsmail Demir1

  • 1Obstetrics and Gynecology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|April 13, 2023
PubMed
Summary
This summary is machine-generated.

Maternal platelet distribution width (PDW) and basophil counts can help predict neonatal asphyxia before birth. Elevated PDW levels may serve as a cost-effective screening tool for identifying at-risk pregnancies.

Keywords:
Apgarasphyxiabasophil countchorioamnionitisinflammationplatelet distribution width (PDW)

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Hematology

Background:

  • Neonatal asphyxia remains a significant cause of mortality and morbidity.
  • While some risk factors are known, asphyxia can occur even in low-risk pregnancies.
  • Predictive markers for asphyxia are crucial for timely intervention.

Purpose of the Study:

  • To investigate maternal hematological parameters for predicting fetal asphyxia.
  • To compare these parameters between mothers of asphyxiated and healthy infants.
  • To identify reliable predictors for asphyxia before birth.

Main Methods:

  • Maternal complete blood count parameters were analyzed.
  • Key parameters included platelet distribution width (PDW), procalcitonin (PCT), and neutrophil/lymphocyte ratio (NLR).
  • Data were collected from mothers of term infants diagnosed with asphyxia and healthy controls.

Main Results:

  • Mothers of infants with asphyxia showed significantly higher PDW and basophil counts (p < .000).
  • PDW levels > 19.425 accurately predicted asphyxia (AUC = 0.724, p = .000).
  • Basophil counts > 0.15 (10³/μL) also predicted asphyxia (AUC = 0.67, p = .000).

Conclusions:

  • Maternal PDW is a potential, cost-effective biomarker for predicting neonatal asphyxia.
  • Basophil count also shows predictive value for asphyxia.
  • Routine maternal blood tests may aid in pre-labor asphyxia risk assessment.