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Published on: April 12, 2021
Ocular complications in live-related renal transplant recipients: A single-centre study
Fatema Ali Lanewala1, Akhtar Jamal Khan1
1Department of Ophthalmology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Abstract:
Renal transplantation is considered to be the treatment of choice for patients with end-stage kidney failure. While transplantation has a high success rate, there are a number of associated challenges which include those related to the primary disease, transplant procedure as well as medications that are necessary to take after transplantation. Steroids, for instance, have been reported to lead to ocular complications in patients who have undergone renal transplantation in other parts of the world. This retrospective case series reports the pattern of ocular complications among patients who underwent renal transplant since the inception of ophthalmology clinic at a dialysis and transplant centre in Karachi, Pakistan. The case series corroborates the findings of other similar studies from around the world, with cataract being the most common occurrence in this cohort. A unique finding in Pakistani setup includes the high prevalence of night blindness, which requires investigation in a larger cohort prospectively.
Insights
Renal transplantation can cause ocular complications, with cataracts being most common. This study in Pakistan also found a high prevalence of night blindness in transplant patients.
Area of Science:
- Nephrology
- Ophthalmology
- Transplantation Medicine
Background:
- Renal transplantation is the primary treatment for end-stage kidney failure.
- Post-transplant challenges include primary disease, surgical factors, and immunosuppressive medications.
- Steroids are known to cause ocular complications in transplant recipients globally.
Purpose of the Study:
- To report the pattern of ocular complications in renal transplant recipients.
- To analyze data from an ophthalmology clinic at a dialysis and transplant center in Karachi, Pakistan.
- To compare findings with international studies and identify unique patterns in the Pakistani population.
Main Methods:
- Retrospective case series design.
- Data collected from patients undergoing renal transplant.
- Analysis of ocular complications observed since the establishment of the ophthalmology clinic.
Main Results:
- Cataract was the most frequent ocular complication observed.
- The findings align with previous international studies on post-renal transplant ocular issues.
- A notable finding was the high prevalence of night blindness in the Pakistani cohort.
Conclusions:
- Cataract is a common ocular complication following renal transplantation.
- The high incidence of night blindness in Pakistani renal transplant recipients warrants further prospective investigation.
- Understanding these patterns can help improve post-transplant patient care and monitoring.
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