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Updated: Aug 2, 2025
Ex Vivo Organoid Model of Adenovirus-Cre Mediated Gene Deletions in Mouse Urothelial Cells
Published on: May 5, 2022
Recent advances in the understanding of urothelial tumorigenesis
Masato Yasui1,2, Liam Cui1, Hiroshi Miyamoto1,2,3
1Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Introduction:
Patients with non-muscle-invasive bladder tumor suffer from disease recurrence following transurethral surgery even with intravesical pharmacotherapy, while muscle-invasive disease is often deadly. It is therefore critical to elucidate the underlying molecular mechanisms responsible for not only bladder tumor progression but also its tumorigenesis. Indeed, various molecules and/or signaling pathways have been suggested to contribute to the pathogenesis of bladder cancer.
Areas Covered:
We summarize the progress during the last few years on the initiation or development, but not progression, of urothelial cancer. The clinical implications of these available data, including prognostic significance and possible application for the prevention of the recurrence of non-muscle-invasive bladder tumors, are also discussed.
Expert Opinion:
Bladder cancer is a heterogeneous group of neoplasms. The establishment of personalized therapeutic options based on the molecular profile in each case should thus be considered. On that account, further accumulation of data on urothelial tumorigenesis is warranted to identify promising targets for the prevention of postoperative tumor recurrence or tumor development in otherwise high-risk patients.
Insights
Understanding bladder cancer initiation is key to preventing recurrence. Further research into urothelial tumorigenesis can identify targets for high-risk patients, improving outcomes for non-muscle-invasive bladder tumors.
Area of Science:
- Uro-oncology
- Molecular mechanisms of cancer
- Bladder cancer research
Background:
- Non-muscle-invasive bladder tumors frequently recur post-surgery, even with treatment.
- Muscle-invasive bladder cancer has a poor prognosis.
- Understanding bladder cancer initiation and development is crucial.
Purpose of the Study:
- To summarize recent advancements in urothelial cancer initiation and development.
- To discuss clinical implications, including prognostic significance.
- To explore applications for preventing non-muscle-invasive bladder tumor recurrence.
Main Methods:
- Literature review of recent progress in urothelial cancer research.
- Analysis of molecular mechanisms and signaling pathways involved in bladder cancer pathogenesis.
- Discussion of clinical data and prognostic significance.
Main Results:
- Recent progress focuses on the initiation and development, rather than progression, of urothelial cancer.
- Molecular insights offer potential for preventing tumor recurrence.
- Personalized therapeutic strategies based on molecular profiles are essential.
Conclusions:
- Further research into urothelial tumorigenesis is necessary.
- Identifying promising targets can aid in preventing postoperative tumor recurrence.
- Personalized medicine approaches are vital for managing bladder cancer heterogeneity.
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