Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

316
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
316
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

628
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
628
MicroRNAs01:22

MicroRNAs

21.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline neutrophil-to-eosinophil ratio and neutrophil-to-lymphocyte ratio as prognostic markers in patients with unresectable biliary tract cancer treated with gemcitabine-cisplatin-durvalumab: an international, multicentre, retrospective cohort study.

ESMO gastrointestinal oncology·2026
Same author

Identifying diagnostic biomarkers in functional motor disorders through multimodal behavioral, neurophysiological, and imaging assessment using explainable machine learning.

Journal of neurology·2026
Same author

Gender differences in non-motor symptoms in Parkinson's disease: a multicenter longitudinal study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

The effect of serial extractions compared to enucleations on skeletal, dental, and soft tissues: a longitudinal evaluation.

European journal of paediatric dentistry·2026
Same author

Early bevacizumab dose and time modifications may affect efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma treatment.

ESMO gastrointestinal oncology·2026
Same author

Loss of serotonergic function in carriers of PRKN mutations: a [<sup>11</sup>C]DASB PET study.

European journal of nuclear medicine and molecular imaging·2026
Same journal

Movement disorders in GLUT1 deficiency syndrome: a systematic review of the literature.

Journal of neurology·2026
Same journal

Detailed clinical characteristics of musical hallucinations in 81 patients.

Journal of neurology·2026
Same journal

The dual role of mTOR in multiple sclerosis pathophysiology: a systematic review.

Journal of neurology·2026
Same journal

Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.

Journal of neurology·2026
Same journal

Spontaneous intracranial hypotension due to pelvic cerebrospinal fluid leak.

Journal of neurology·2026
Same journal

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026
See all related articles

Related Experiment Video

Updated: Aug 2, 2025

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

7.6K

Gender differences in microRNA expression in levodopa-naive PD patients.

A Vallelunga1, T Iannitti2, G Somma3

  • 1Department of Life Sciences and Biotechnologies, Section of Medicines and Health Products, University of Ferrara, Ferrara, Italy.

Journal of Neurology
|April 13, 2023
PubMed
Summary
This summary is machine-generated.

Gender influences Parkinson's disease (PD) progression. This study found specific microRNA (miRNA) levels differ between male and female PD patients, suggesting potential gender-specific disease mechanisms.

Keywords:
Gender differencesParkinson’s diseaseTarget genesmiRNAs

More Related Videos

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.6K

Related Experiment Videos

Last Updated: Aug 2, 2025

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

7.6K
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Parkinson's disease (PD) exhibits gender-specific epidemiological and clinical characteristics.
  • MicroRNAs (miRNAs) are implicated in the pathophysiology and progression of neurodegenerative diseases.
  • Understanding gender differences in miRNA expression may reveal novel therapeutic targets for PD.

Purpose of the Study:

  • To investigate gender-specific differences in the serum expression of selected miRNAs in Parkinson's disease patients.
  • To explore potential correlations between miRNA expression levels and clinical parameters in PD.
  • To identify potential biological pathways influenced by gender-specific miRNA expression in PD.

Main Methods:

  • Serum samples were collected from 104 de novo Parkinson's disease patients (58 males, 46 females).
  • Quantitative PCR was employed to measure the expression levels of miR-34a-5p, miR-146a, miR-155, miR-29a, and miR-106a.
  • Spearman's correlation test and STRING database analysis were used to assess relationships between miRNA expression, clinical data, and gene co-expression networks.

Main Results:

  • miR-34a-5p was significantly upregulated in male PD patients compared to female PD patients (fold change: 1.62, p < 0.0001).
  • miR-146a-5p was significantly upregulated in female PD patients compared to male PD patients (fold change: 3.44, p < 0.0001), with higher expression correlating with longer disease duration.
  • No significant gender-based differences were observed for miR-29a, miR-106a-5p, and miR-155 expression; no correlations with age, BMI, or UPDRS III scores were found.

Conclusions:

  • The study provides evidence for gender-specific differences in serum miRNA expression profiles in Parkinson's disease patients.
  • These identified miRNAs (miR-34a-5p and miR-146a-5p) may play distinct roles in the pathogenesis or progression of PD between genders.
  • Further longitudinal studies are warranted to determine if these miRNA expression differences impact disease progression and treatment response in PD.