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Updated: Aug 2, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Lung preservation: from perfusion to temperature.

Bianca Bromberger1, Marek Brzezinski2, Jasleen Kukreja3

  • 1Division of Cardiothoracic Surgery.

Current Opinion in Organ Transplantation
|April 13, 2023
PubMed
Summary

Ex-vivo lung perfusion and novel static cold storage research are advancing lung transplantation. These innovations aim to improve donor lung utilization and transplantation outcomes, potentially reshaping current standards of care.

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Last Updated: Aug 2, 2025

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Area of Science:

  • Cardiovascular and Respiratory System Science
  • Transplantation Medicine
  • Organ Preservation Technology

Background:

  • Lung preservation is critical for successful post-transplant lung function.
  • Established methods for lung preservation have seen minimal changes over the last decade.
  • Emerging technologies and research are poised to significantly impact lung transplantation protocols.

Conclusions:

  • Understanding organ preservation principles is vital for optimal lung transplant outcomes.
  • Recent innovations in EVLP and SCS temperature research may challenge existing lung preservation standards.
  • These advancements have the potential to reshape lung transplantation practices.