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Related Experiment Video

Updated: Aug 2, 2025

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

Primary graft dysfunction after lung transplantation.

Mallory L Hunt¹, Edward Cantu

¹Division of Cardiovascular Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Current Opinion in Organ Transplantation

|April 13, 2023

Summary

This summary is machine-generated.

Primary graft dysfunction (PGD) after lung transplantation involves lung injury and inflammation. Research identifies risk factors and supportive care, including ECMO, to manage PGD and improve outcomes.

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Last Updated: Aug 2, 2025

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

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Published on: October 11, 2024

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

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Published on: July 10, 2012

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Published on: August 15, 2022

Area of Science:

Pulmonology
Transplantation immunology
Critical care medicine

Background:

Primary graft dysfunction (PGD) is a major complication following lung transplantation, occurring within 72 hours.
It is characterized by hypoxemia and alveolar infiltrates, stemming from ischemia-reperfusion injury.
PGD involves a complex interaction of donor/recipient immunity and acute inflammation, leading to alveolar cell damage.

Conclusions:

Understanding PGD pathogenesis is key to developing effective mitigation strategies.
Multifactorial risk assessment and tailored supportive care are essential.
Emerging technologies like EVLP warrant further investigation for their role in improving lung transplant outcomes.