[Results of peridural morphine analgesia in the early postoperative period]

The influence of age, concomitant atherosclerosis and pregnancy on the efficiency of postoperative peridural analgesia with morphine was studied in 2000 patients. It was found that the incidence of adequate analgesia was linearly increased with the age of the patients and the morphine dose. The influence of atherosclerosis and pregnancy manifested itself in the improvement of the analgetic and sedative effect of morphine. The data obtained are thought to be associated with changed permeability of diffuse barriers for the analgetics.