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Barriers to progress in pregnancy research: How can we break through?
Sarah J Stock1,2,3, Catherine E Aiken4,5,6
1University of Edinburgh Usher Institute, Edinburgh EH16 4UX, UK.
Science (New York, N.Y.)
|April 13, 2023
Summary
Understanding healthy pregnancy is crucial for developing new therapies. New research uses advanced models like trophoblast organoids and data science to study the maternal-placental-fetal system and identify therapeutic targets.
Area of Science:
- Reproductive biology and maternal-fetal medicine.
- Developmental biology and placental research.
Background:
- Healthy pregnancies are vital for population health, yet therapeutic options for improving pregnancy outcomes are scarce.
- Fundamental aspects of pregnancy, including placentation and labor onset mechanisms, are not fully understood.
- The complexity of the tripartite maternal-placental-fetal system and its dynamic changes throughout gestation present significant research challenges.
Purpose of the Study:
- To highlight the challenges in studying pregnancy disorders.
- To introduce novel approaches for investigating pregnancy physiology.
- To identify potential therapeutic targets for pregnancy complications.
Main Methods:
- Utilizing trophoblast organoids to model placental development in vitro.
- Employing integrated data-science approaches to analyze long-term pregnancy outcomes.
- Addressing the limitations of in vitro maternal-placental-fetal interfaces and animal models.
Main Results:
- Newer methodologies offer improved insights into placental development.
- Data science approaches aid in understanding complex pregnancy dynamics.
- These methods facilitate the study of the maternal-placental-fetal system's intricacies.
Conclusions:
- Advanced research methods, including organoids and data science, are essential for understanding healthy pregnancy.
- These approaches provide a foundation for identifying therapeutic targets for pregnancy disorders.
- Further research into placental development and maternal-fetal interactions is critical for improving maternal and infant health.
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