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Related Experiment Video

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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
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Networking between helminths, microbes, and mammals.

P'ng Loke1, Nicola L Harris2

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|April 13, 2023
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Mammals and their gut microbes have coevolved, but intestinal helminths also shape host evolution. Understanding the immune system

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Area of Science:

  • Immunology
  • Microbiology
  • Parasitology

Background:

  • Mammals coevolve with gut microbiota.
  • Intestinal helminths are significant selective pressures on mammalian hosts.
  • The host immune system mediates interactions between helminths, microbes, and hosts.

Approach:

  • This review highlights the complex interplay between helminths, microbes, and mammalian hosts.
  • Focuses on the host immune system as a critical interface.
  • Examines how helminths and microbiota influence tissue homeostasis and immunity.

Key Points:

  • Crosstalk between helminths, microbiota, and the immune system dictates tolerance vs. resistance.
  • Helminths and microbiota impact tissue homeostasis and immune regulation.
  • Cellular and molecular mechanisms underlying these interactions are crucial.

Conclusions:

  • Understanding the host immune system's role in helminth and microbiota interactions is crucial.
  • This knowledge can guide the development of novel treatment approaches for parasitic infections.
  • Further research at cellular and molecular levels is warranted.