Related Experiment Video
Updated: Aug 2, 2025
03:56
A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy
Published on: September 13, 2022
2.4K
Nephrolithiasis in two patients on iron chelation therapy: A case report
Hannah Dillon1, Zoë Baker2, Adam Pena3
1Division of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Summary
Iron chelation therapy drugs like deferasirox, deferiprone, and deferoxamine may increase the risk of kidney stones in children with iron overload. Further research is needed to understand this link.
Area of Science:
- Nephrology
- Pediatric Hematology
- Pharmacology
Background:
- Drug-induced nephrolithiasis is a known complication of certain medications.
- Iron chelation therapy (ICT) is crucial for managing iron overload in patients with chronic transfusion needs.
- The specific risk of nephrolithiasis associated with commonly used ICT agents is not well-established.
Observation:
- This report details two pediatric cases of nephrolithiasis.
- Patients were undergoing treatment for iron overload secondary to repeated blood transfusions.
- The patients were treated with deferasirox, deferiprone, and deferoxamine.
Findings:
- Nephrolithiasis was diagnosed in pediatric patients receiving ICT.
- The development of kidney stones occurred during treatment with deferasirox, deferiprone, and deferoxamine.
- This suggests a potential association between these ICT agents and nephrolithiasis in children.
Implications:
- These findings highlight a potential adverse effect of ICT agents in pediatric patients.
- Further investigation is warranted to confirm the causal relationship between ICT and nephrolithiasis.
- Clinical monitoring for nephrolithiasis may be beneficial for pediatric patients undergoing ICT.
Related Concept Videos
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
13
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
13
01:30Urinary Tract Calculi III: Medical Management
10
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
10
01:28Urinary Tract Calculi V: Nursing Management
15
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
15
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
19
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
19
01:28Chronic Kidney Disease III: Interprofessional Care
59
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
59
01:24Chronic Kidney Disease II: Clinical Manifestations
48
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
48