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Nephrolithiasis in two patients on iron chelation therapy: A case report
Hannah Dillon1, Zoë Baker2, Adam Pena3
1Division of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Abstract:
Drug-induced nephrolithiasis can arise from insoluble components within medications or crystallization of metabolites due to changes in metabolism and urinary pH. The connection between drugs utilized for iron chelation therapy (ICT) and nephrolithiasis is not well understood. In this report, we describe two pediatric patients diagnosed with nephrolithiasis while undergoing treatment with the chelating agents deferasirox, deferiprone, and deferoxamine for iron overload secondary to repeat blood transfusion.
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