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Programming of metabolism by adipokines during development.
1Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil. jdonato@icb.usp.br.
Nature Reviews. Endocrinology
|April 13, 2023
Summary
Maternal nutrition during development programs future health. Early life nutritional insults affecting adipokines (hormones from fat tissue) can lead to obesity and type 2 diabetes later in life.
Area of Science:
- Endocrinology
- Developmental Biology
- Metabolic Health
Background:
- Early life development is sensitive to maternal nutrition, influencing long-term health.
- Undernutrition and overnutrition during development can cause metabolic diseases like obesity and type 2 diabetes (metabolic programming).
- Adipokines, signaling molecules from adipose tissue, regulate energy and glucose balance.
Purpose of the Study:
- To review the role of adipokines in metabolic programming during early development.
- To understand how early nutritional insults impact adipokine function and long-term metabolic health.
- To identify key endocrine factors involved in developmental origins of metabolic disease.
Main Methods:
- Literature review focusing on adipokines and metabolic programming.
- Analysis of studies investigating nutritional impacts on adipokine signaling during development.
- Synthesis of evidence linking early life adipokine alterations to adult metabolic disease.
Main Results:
- Adipokines influence various developmental processes relevant to metabolic health.
- Nutritional insults in early life can disrupt adipokine secretion and signaling pathways.
- Altered adipokine function during development is implicated in the pathogenesis of obesity and type 2 diabetes.
Conclusions:
- Adipokines play a critical role in mediating metabolic programming.
- Understanding adipokine roles in early development is crucial for preventing metabolic diseases.
- Targeting adipokine pathways may offer novel strategies for metabolic disease prevention and treatment.
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