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Updated: Aug 2, 2025

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γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway

Ling Xie1, Juan Yan2

  • 1Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Hereditas
|April 13, 2023
PubMed
Abstract

Insights

Gamma-tocotrienol (γ-T3) may treat gastric cancer by inhibiting the notch signaling pathway. This study explored γ-T3

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Gastric cancer is a leading cause of cancer mortality globally.
  • There is a critical need for novel therapeutic targets and drugs for gastric cancer treatment.
  • Tocotrienols (T3) exhibit promising anticancer properties in various cancer cell lines.

Purpose of the Study:

  • To investigate the underlying mechanisms of gamma-tocotrienol (γ-T3) in gastric cancer therapy.
  • To build upon previous findings that γ-T3 induces apoptosis in gastric cancer cells.
  • To identify specific molecular pathways affected by γ-T3 treatment.

Main Methods:

  • Gastric cancer cells were treated with γ-T3.
  • RNA sequencing (RNA-seq) was performed on treated and untreated gastric cancer cells.
  • Analysis of mRNA, ncRNA, and signaling pathway alterations was conducted.

Main Results:

  • γ-T3 treatment inhibited mitochondrial complexes and oxidative phosphorylation in gastric cancer cells.
  • Significant alterations in mRNA and ncRNA expression were observed post γ-T3 treatment.
  • The human papillomavirus (HPV) infection and notch signaling pathways were significantly altered, with down-regulation of Notch1 and Notch2 genes.

Conclusions:

  • γ-T3 shows potential as a therapeutic agent for gastric cancer by inhibiting the notch signaling pathway.
  • This research provides a foundation for developing new clinical treatments for gastric cancer.
  • Targeting the notch signaling pathway with γ-T3 represents a novel therapeutic strategy.
Keywords:
Gastric cancerMitochondriaNotch signaling pathwayOxidative phosphorylationγ-tocotrienol

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