Electrochemical Protein-based Bioanalytical Devices for Drug Analysis

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Nanotechnology

Background:

• Protein dysfunction is linked to various diseases, necessitating protein microenvironment studies for therapeutic development.
• Analytical assays for proteins, drugs, and complexes are crucial for research and clinical applications.
• Electrochemistry provides a scalable, miniaturizable platform for rapid biomolecular assessment.

Approach:

• This review summarizes electrochemical investigations of protein-based analytical devices and biosensors over the last decade.
• It presents an overview of electrochemical assays integrating proteins with nanomaterials and conductive polymers.
• Applications are categorized into drug screening, metabolism, delivery, and quantitative drug assays.

Key Points:

• Electrochemical methods enable fast assessment of proteins and drugs, adaptable for personalized medical care.
• Applications include targeting protein functions, aggregation, and degradation pathways for drug screening.
• Drug metabolism, delivery systems, and quantitative assays leverage electrochemical principles.

Conclusions:

• Electrochemical biosensors are versatile tools for analyzing proteins and drugs.
• These technologies support drug development, personalized medicine, and clinical diagnostics.
• Continued research in nanostructured materials and conductive polymers enhances biosensor capabilities.