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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

176
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
176
Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Related Experiment Video

Updated: Aug 2, 2025

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
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Autism Spectrum Disorders: Advances in Proteomics.

Hui Zhou1, Xiao-Li Feng1,2

  • 1Department of Physiology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China.

Protein and Peptide Letters
|April 14, 2023
PubMed
Summary

Autism Spectrum Disorder (ASD) lacks a cure, necessitating early diagnosis through biomarker discovery. Identifying specific protein markers could significantly advance autism research and treatment strategies.

Keywords:
Animal modelsautismbiomarkermultiple tissue samplesprotein interactionspectrum disordersstage of development

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Area of Science:

  • Neurodevelopmental Disorders
  • Biomarker Discovery
  • Autism Spectrum Disorder Research

Background:

  • Autism Spectrum Disorder (ASD) is a lifelong developmental disability with significant patient impact.
  • Current interventions for ASD are most effective in early childhood, with limited efficacy in older individuals.
  • Effective therapies and early diagnosis for ASD are critically needed.

Purpose of the Study:

  • To highlight the importance of early diagnosis in Autism Spectrum Disorder.
  • To discuss the potential of protein biomarkers for early ASD detection.
  • To emphasize the need for identifying valid biomarkers for mechanistic studies of ASD.

Main Methods:

  • Review of current diagnostic approaches for ASD.
  • Discussion of high-throughput assays for screening differentially expressed proteins.
  • Identification of protein classes investigated as potential ASD markers (e.g., synaptic scaffolding proteins, microtubule-associated proteins).

Main Results:

  • Early diagnosis of ASD is crucial for effective intervention.
  • High-throughput assays are employed to identify potential protein biomarkers.
  • Several protein categories show promise as differential markers in ASD patients.

Conclusions:

  • The identification of reliable autism biomarkers is essential for advancing diagnostic capabilities.
  • Biomarker discovery can facilitate mechanistic studies and the development of novel therapies for ASD.
  • Finding a valid biomarker would represent a significant breakthrough in autism research.