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Post COVID-19 AA amyloidosis of the kidneys with rapidly progressive renal failure
Tajamul H Mir1,2, Parvaiz A Zargar3, Alok Sharma4
1Department of Nephrology, Government Medical College, Srinagar, Jammu and Kashmir, India.
Insights
This case study highlights a rare instance of AA amyloidosis complicating moderate COVID-19 pneumonia, leading to rapid kidney failure and heart issues. Further research is needed to confirm the link between COVID-19 and this kidney complication.
Area of Science:
- Nephrology
- Infectious Diseases
- Cardiology
Background:
- The COVID-19 pandemic presents significant challenges, with organ dysfunction common in critical cases.
- Pulmonary and cardiovascular involvement are leading causes of mortality, but kidney complications are increasingly recognized.
- Acute kidney injury (AKI) and other glomerular diseases like collapsing FSGS and thrombotic microangiopathies have been linked to COVID-19.
Abstract:
Coronavirus disease 2019 (COVID-19) pandemic has taken the world by a storm, posing a gruelling challenge to the medical fraternity globally. Besides its very high infectivityinfectivity, significant organ dysfunction occurs in critically ill COVID-19 patients, leading to severe morbidity and mortality. Pulmonary involvement is the leading cause of death in these patients to be followed by the cardiovascular involvement. Kidney involvement due to COVID-19 is becoming more discernible with AKI adversely affecting the outcome. Besides AKI, a few cases of collapsing FSGS in genetically vulnerable patients and thrombotic microangiopathies have been reported as well. We report a case of AA amyloidosis of the kidney with a rapidly progressive renal failure and congestive heart failure with preserved left ventricular functions, which complicated a moderate COVID-19 pneumonia providing some clues to a possible association of this novel virus disease with this complication, which needs to be confirmed in future studies.
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