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Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
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Functional microspheres for tissue regeneration.

Qian Li1, Bei Chang1, He Dong2

  • 1Department of Biomedical Sciences, School of Dentistry, Texas A&M University, Dallas, TX, 75246, USA.

Bioactive Materials
|April 14, 2023
PubMed
Summary
This summary is machine-generated.

Functional microspheres are advanced injectable biomaterials revolutionizing tissue regeneration. This review details their fabrication, novel structures, and applications in regenerating various tissues, highlighting future potential.

Keywords:
BiodegradableInjectableMicrosphereScaffoldTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Functional microspheres are emerging injectable biomaterials offering advantages over traditional hydrogels in tissue regeneration.
  • Recent advancements have led to diverse bio-inspired microspheres utilized as cellular carriers and drug delivery systems.

Purpose of the Study:

  • To provide a comprehensive review of functional and biodegradable microspheres for tissue regeneration over the past two decades.
  • To summarize recent technological progress in preparing advanced functional microspheres.
  • To discuss the specific applications of these microspheres in various tissue regeneration contexts.

Main Methods:

  • Review of literature on functional and biodegradable microspheres used in tissue regeneration.
  • Categorization of microsphere fabrication methods.
  • Analysis of advanced microsphere preparation technologies (macroporous, nanofibrous, hollow, core-shell, surface-modified).
  • Discussion of applications in bone, cartilage, dental, neural, cardiac, and skin tissue regeneration.

Main Results:

  • Significant progress in developing functional microspheres with unique structures and properties.
  • Demonstrated utility of various microsphere types as effective carriers for tissue regeneration.
  • Broad applicability across multiple tissue types, including bone, cartilage, neural, and skin.

Conclusions:

  • Functional microspheres represent a promising class of injectable biomaterials for tissue regeneration.
  • Continued innovation in microsphere design and fabrication will further advance their therapeutic potential.
  • Future research should focus on optimizing these carriers for enhanced clinical translation in regenerative medicine.