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Is Chronic Kidney Disease, a Predictor of In-Hospital Mortality in Coronavirus Disease 2019 (COVID-19) Patients?

Firouzeh Moeinzadeh1, Vahideh Raeisi2, Media Babahajiani3

  • 1Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Advanced Biomedical Research
|April 14, 2023
PubMed

Insights

Chronic kidney disease (CKD) significantly increased COVID-19 mortality risk in initial analysis. However, after adjusting for other factors, this association was no longer significant, suggesting CKD may not be an independent predictor of mortality in COVID-19 patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Chronic kidney disease (CKD) is a prevalent comorbidity among patients with Coronavirus Disease 2019 (COVID-19).
  • Understanding the impact of CKD on COVID-19 outcomes is crucial for patient management.

Purpose of the Study:

  • To investigate the association between chronic kidney disease (CKD) and in-hospital mortality in patients diagnosed with Coronavirus Disease 2019 (COVID-19).

Main Methods:

  • A cohort study involving 116 CKD patients and 147 control subjects with confirmed COVID-19.
  • Data collected included demographics, clinical signs, symptoms, laboratory findings, and chest CT scans.
  • Logistic regression models were employed to analyze the association between CKD and in-hospital mortality, with adjustments for confounders.

Main Results:

  • The mortality rate was substantially higher in COVID-19 patients with CKD compared to those without (30.17% vs 4.76%, P < 0.001).
  • Crude logistic regression indicated a significant correlation between CKD and in-hospital mortality (OR = 8.64).
  • However, after full adjustment for confounders, the association between CKD and in-hospital mortality was not statistically significant in the total sample or gender subgroups (OR = 1.70).

Conclusions:

  • While initial analyses suggested a link, this study indicates that chronic kidney disease (CKD) may not be an independent predictor of in-hospital mortality in COVID-19 patients after accounting for other risk factors.
  • Intensive monitoring of COVID-19 patients with CKD is still recommended due to their higher observed mortality rates.
Abstract

Keywords:
COVID-19Chronic kidney diseasein-hospital mortalityrisk factors

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