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Fullerene-polysaccharide supramolecular hydrogel displaying antioxidation/antiglycation behavior
Hong-Mei Yu1,2, Xiao-Yong Yu3, Yong Chen3
1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Soft Matter
|April 14, 2023
Summary
A novel fullerene-polysaccharide hydrogel was developed, showing strong antioxidant and antiglycation properties. This innovative material holds promise for advanced cosmetic applications due to enhanced fullerene solubility and activity.
Area of Science:
- Materials Science
- Biotechnology
- Cosmetic Science
Background:
- Fullerenes possess potent antioxidant properties but suffer from poor water solubility and bioavailability.
- Cyclodextrins can encapsulate hydrophobic molecules, enhancing their solubility and biological activity.
- Polysaccharides like chitosan and clays like bentonite are widely used in biomaterials and cosmetics.
Purpose of the Study:
- To construct a fullerene-polysaccharide supramolecular hydrogel with enhanced antioxidant and antiglycation properties.
- To improve the water solubility and biological activity of fullerene through complexation with hydroxypropyl-β-cyclodextrin.
- To explore the potential of this novel hydrogel for cosmetic applications.
Main Methods:
- Co-assembly of fullerene@hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex with chitosan and bentonite.
- Formation of a ternary co-assembly supramolecular hydrogel.
- Evaluation of antioxidant activity using oxygen radical absorbance capacity and pyrogallol autoxidation assays.
- Assessment of antiglycation properties by measuring the inhibition rate of glycation end products.
Main Results:
- A stoichiometric 2:1 fullerene@HP-β-CD complex was formed with an encapsulation ratio of 79%, significantly enhancing fullerene's water solubility and activity.
- The fullerene@HP-β-CD inclusion complex demonstrated high antioxidant activity.
- The resulting supramolecular hydrogel exhibited significant antiglycation properties, with a 43.99% inhibition rate of glycation end products at 10% concentration.
- Multiple hydrogen bonds and electrostatic interactions facilitated the ternary co-assembly into a stable hydrogel structure.
Conclusions:
- A novel fullerene-polysaccharide ternary co-assembly supramolecular hydrogel was successfully constructed.
- The hydrogel possesses excellent antioxidant and antiglycation capabilities, making it a promising candidate for cosmetic formulations.
- This study offers a new perspective on utilizing polysaccharide-based supramolecular hydrogels as functional raw materials in the cosmetics industry.
