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Updated: Aug 2, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding
Chrystal Lopes1, Yohann Cartigny1, Clément Brandel1
1Univ Rouen Normandie SMS, UR 3233, 76000, Rouen, France.
Abstract:
We report the first case of mechanochemical deracemization by using liquid-assisted abrasive grinding. The target molecule is a precursor of Paclobutrazol, an important fungicide and plant growth inhibitor. Using mechanochemical deracemization, we are even able to transform a 10 % ee scalemic mixture of this latter in an enantioenriched product of 97 % ee in a couple of hours. This is substantially shorter compared to solution-based deracemization methodologies. The present paper thus introduces an efficient and greener process to enantiopure material.
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