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Updated: Aug 2, 2025

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
Brønsted Acid Catalyzed Asymmetric Synthesis of cis-Tetrahydrocannabinoids
Caroline Dorsch1, Christoph Schneider1
1Department of Chemistry and Mineralogy, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany.
Abstract:
We report herein the catalytic asymmetric cyclization of 1-aryl terpenols to afford enantiomerically highly enriched Δ9 -cis-tetrahydrocannabinoid scaffolds in a single step. As powerful chiral catalysts strongly acidic imidodiphosphorimidates (IDPis) have been identified which furnish the products with good yields and excellent enantioselectivity. Upon MOM-deprotection some naturally occurring cannabimimetica such as (-)-cis-Δ9 -tetrahydrocannabinol and (-)-perrottetinene as well as some unnatural analogues were made accessible along a merely 3-step biomimetic sequence (MOM=methoxymethyl).
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