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Updated: Aug 2, 2025
04:14
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
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Intermittent fasting-the future treatment in NASH patients?
Iulia Minciuna1,2, Suchira Gallage3,4, Mathias Heikenwalder4,3
1Regional Institute of Gastroenterology and Hepatology Octavian Fodor, Cluj-Napoca, Romania.
Hepatology (Baltimore, Md.)
|April 14, 2023
Summary
Intermittent fasting shows promise for treating non-alcoholic steatohepatitis (NASH), a major cause of chronic liver disease. This approach may improve metabolic health and reduce liver disease progression by targeting key NASH drivers.
Area of Science:
- Hepatology and Metabolic Diseases
- Gastroenterology
Background:
- Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, potentially progressing to end-stage liver disease and hepatocellular carcinoma (HCC).
- NASH significantly burdens healthcare systems, including non-cirrhotic patients, and is an increasing indication for liver transplantation.
Approach:
- This review explores the metabolic drivers of NASH pathogenesis.
- It examines how intermittent fasting (IF) interventions can target these drivers.
- The review summarizes current clinical evidence on IF for NASH management.
Key Points:
- Intermittent fasting aids weight loss and improves cardiometabolic parameters like blood pressure, lipids, and glucose metabolism.
- IF reduces key NASH-related cellular stressors including inflammation, endoplasmic reticulum stress, and oxidative stress.
- Intermittent fasting also modulates gut microbiota and improves endothelial function.
Conclusions:
- Intermittent fasting presents a promising therapeutic strategy for NASH by addressing its core metabolic and inflammatory pathways.
- Further clinical research is warranted to fully establish the efficacy of intermittent fasting in improving NASH prognosis.
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