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Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes

Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes

Published on: May 21, 2018

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple

Em P Harrington^1,2,3, Riley B Catenacci^1,2, Matthew D Smith¹

¹Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States.

|April 14, 2023

Abstract:

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.

Keywords:

immunology inflammation major histocompatibility complex mouse multiple sclerosis neuroscience oligodendrocytes

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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Keywords:

immunology inflammation major histocompatibility complex mouse multiple sclerosis neuroscience oligodendrocytes

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