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Clinical Features and Blood Indicators for Severity and Prognosis in COVID-19 Patients

Jingjie Liu, Shouping Gong, Jianrui Lv

    Clinical Laboratory
    |April 14, 2023
    PubMed

    Insights

    Clinical manifestations and blood indicators in COVID-19 patients were analyzed. Critical illness in Coronavirus disease 2019 (COVID-19) may be indicated by advanced age and specific blood markers, including white blood cell (WBC) and C-reactive protein (CRP).

    Area of Science:

    • Infectious Diseases
    • Hematology
    • Critical Care Medicine

    Background:

    • Coronavirus disease 2019 (COVID-19) presents with diverse clinical manifestations.
    • Understanding key clinical and hematological indicators is crucial for managing COVID-19 patients.

    Purpose of the Study:

    • To analyze clinical signs and blood indicators in COVID-19 patients.
    • To identify predictors of critical illness and mortality in COVID-19.

    Main Methods:

    • Retrospective analysis of 61 hospitalized COVID-19 patients.
    • Comparison of clinical and laboratory data between non-critical and critical groups, and between survivors and non-survivors.

    Main Results:

    • Critical COVID-19 patients exhibited higher age, fever rates, and elevated levels of white blood cell (WBC), basophils, lactate dehydrogenase (LDH), C-reactive protein (CRP), high-sensitivity troponin, pro-brain natriuretic peptide (pro-BNP), prothrombin time (PT), and D-dimer.
    • Lower levels of lymphocytes, eosinophils, and albumin were observed in critical patients.
    • WBC, basophils, and LDH were significantly higher in the non-surviving subgroup compared to survivors.

    Conclusions:

    • Advanced age, high fever, and specific hematological markers (elevated WBC, basophils, CRP, LDH, troponin, pro-BNP, D-dimer; decreased lymphocytes, eosinophils, albumin) may predict critical COVID-19.
    • These indicators can aid in early identification and management of severe cases.
    • Hematological parameters offer valuable insights into COVID-19 severity and prognosis.
    Abstract

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