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Association between widespread pain and associated symptoms in patients with cirrhosis
Alexis Holman1, Neehar D Parikh2, Zhe Zhao2
1Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA.
Background:
Chronic pain is common in cirrhosis; however, the mechanistic classifications are not well characterized. Nociplastic pain, for instance, is associated with comorbid nonpain symptoms and responds to different treatments than nociceptive pain.
Methods:
We conducted a survey study in February 2022 of adult patients with cirrhosis at the University of Michigan (N = 238) to evaluate pain widespreadedness, associated nociplastic symptoms, and pain intensity.
Findings:
Pain and pain widespreadedness were associated with mood and cognitive disturbance, fatigue, sleep difficulty, and physical and social functioning. Patient-reported Outcomes, such as body maps, can be useful to phenotype patients for pain mechanisms.
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