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[Neuropsychiatric disorders in multiple sclerosis]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1986
Summary
This study on multiple sclerosis (MS) found that structural brain changes are key to psychic disorders. A differential treatment approach using various medications and psychotherapy is proposed for MS patients.
Area of Science:
- Neurology
- Psychiatry
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Psychic disorders are common in MS patients, impacting quality of life.
Purpose of the Study:
- To investigate the relationship between structural brain changes and psychic disorders in multiple sclerosis (MS) patients.
- To identify the main syndromes of psychic disorders in MS.
- To propose a differential treatment approach.
Main Methods:
- A comprehensive randomized study of 138 MS patients.
- Clinical follow-up, including neuroimaging (CT, EEG, rheoencephalography, echoencephalography).
- Psychological and experimental examinations were conducted on a subset of patients.
Main Results:
- Identified key psychic disorder syndromes in MS: neurosis-like, affective, organic oligophrenia, psychotic states, and epileptiform syndrome.
- Structural brain changes were identified as the principal factor in the genesis of these disorders.
- Long-term follow-up (up to 4 years) was conducted on 56 patients.
Conclusions:
- Structural brain abnormalities are central to the development of psychic disorders in MS.
- A tailored treatment strategy is recommended, incorporating pharmacotherapy (tranquilizers, antidepressants, neuroleptics, nootropics) and psychotherapy.