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[Neuropsychiatric disorders in multiple sclerosis].

Iu S Marynov, G F Malkov

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1986
    PubMed
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    This study on multiple sclerosis (MS) found that structural brain changes are key to psychic disorders. A differential treatment approach using various medications and psychotherapy is proposed for MS patients.

    Area of Science:

    • Neurology
    • Psychiatry

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Psychic disorders are common in MS patients, impacting quality of life.

    Purpose of the Study:

    • To investigate the relationship between structural brain changes and psychic disorders in multiple sclerosis (MS) patients.
    • To identify the main syndromes of psychic disorders in MS.
    • To propose a differential treatment approach.

    Main Methods:

    • A comprehensive randomized study of 138 MS patients.
    • Clinical follow-up, including neuroimaging (CT, EEG, rheoencephalography, echoencephalography).
    • Psychological and experimental examinations were conducted on a subset of patients.

    Main Results:

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    • Identified key psychic disorder syndromes in MS: neurosis-like, affective, organic oligophrenia, psychotic states, and epileptiform syndrome.
    • Structural brain changes were identified as the principal factor in the genesis of these disorders.
    • Long-term follow-up (up to 4 years) was conducted on 56 patients.

    Conclusions:

    • Structural brain abnormalities are central to the development of psychic disorders in MS.
    • A tailored treatment strategy is recommended, incorporating pharmacotherapy (tranquilizers, antidepressants, neuroleptics, nootropics) and psychotherapy.