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Updated: Sep 27, 2026
15:48
ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
[Pathogenetic mechanisms and therapy of a subclinical form of Lesch-Nyhan syndrome]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1986
Abstract:
The results of clinical, experimental psychological and biochemical studies of patients with a subclinical form of Lesch-Nyhan syndrome suggested a reduction of the inhibitory influence of the caudate nucleus due to incomplete genetic defect of Hg-PRTase and related disorders of other types of metabolism in the area of basal ganglia as one of the links of pathogenesis. The pathogenetic therapy is based on maintaining high activity of Hg-PRTase by dietary treatment with limited intake of exogenous purines.
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