Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

21
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
21
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

27
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
27

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS.

Critical care (London, England)·2026
Same author

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Pulse Oximetry, Skin Pigmentation, and Occult Hypoxemia in Pediatric Cardiac Critical Care.

Pediatric cardiology·2026
Same author

Point-of-Care Ultrasound Foundations in Physics and Image Acquisition: An Innovative Hands-on Active Learning Workshop.

MedEdPORTAL : the journal of teaching and learning resources·2026
Same author

Adherence to hepatitis B birth dose vaccine recommendations in two hospital systems in Houston.

Vaccine·2026
Same author

Shaping Kale Morphology and Physiology Using Precision LED Light Recipes.

Journal of experimental botany·2026

Related Experiment Video

Updated: Aug 2, 2025

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
07:48

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

7.7K

Elevated bile acids are associated with left ventricular structural changes in biliary atresia.

Manpreet K Virk1, Muhammad Umair M Mian2, Dalia A Bashir1

  • 1Department of Pediatrics, Section of Critical Care Medicine, Texas Children's Hospital Baylor College of Medicine, Houston, Texas, USA.

Hepatology Communications
|April 14, 2023
PubMed
Summary

High bile acid levels in children with biliary atresia (BA) are linked to abnormal heart structure, suggesting bile acids may trigger cardiac changes. This finding offers a potential target for treatment.

More Related Videos

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

2.6K
Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

6.9K

Related Experiment Videos

Last Updated: Aug 2, 2025

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
07:48

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

Published on: October 13, 2018

7.7K
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

2.6K
Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

6.9K

Area of Science:

  • Pediatric Cardiology
  • Gastroenterology
  • Biochemistry

Background:

  • Biliary atresia (BA) in children can lead to cirrhotic cardiomyopathy, impacting heart structure and perioperative outcomes.
  • The precise triggers and pathogenesis of this cardiac remodeling in BA remain unclear.
  • While bile acid excess is known to cause cardiomyopathy in experimental cirrhosis, its role in BA is not well understood.

Purpose of the Study:

  • To investigate the association between serum bile acid concentrations and left ventricular (LV) geometry in children with BA.
  • To identify potential threshold values of bile acids indicative of pathologic LV changes.
  • To explore the presence of the bile acid-sensing receptor Takeda G-protein-coupled membrane receptor type 5 in cardiac tissue.

Main Methods:

  • Echocardiographic parameters (LV mass, indexed LVM, indexed LAVI, LVID) were measured in 40 children with BA.
  • Serum bile acid concentrations were correlated with echocardiographic findings.
  • A receiver-operating characteristic curve analysis determined optimal bile acid thresholds.
  • Immunohistochemistry analyzed human heart tissue for Takeda G-protein-coupled membrane receptor type 5.

Main Results:

  • Over half (52%) of the children exhibited abnormal LV geometry.
  • A serum bile acid concentration of 152 µmol/L was identified as a threshold for detecting abnormal LV geometry (70% sensitivity, 64% specificity).
  • Children with bile acid levels >152 µmol/L had an approximately 8-fold increased risk of LV abnormalities.
  • Serum bile acids showed a positive correlation with LVM, indexed LVM, and LVID.
  • Takeda G-protein-coupled membrane receptor type 5 was detected in cardiac vasculature and cardiomyocytes.

Conclusions:

  • Elevated serum bile acids are associated with abnormal cardiac structure in children with biliary atresia.
  • Bile acids represent a potential targetable trigger for myocardial structural changes in BA.
  • These findings underscore the importance of monitoring bile acid levels in pediatric BA patients.