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Immune checkpoint therapy-current perspectives and future directions

Padmanee Sharma1, Sangeeta Goswami2, Deblina Raychaudhuri3

  • 1Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cell
|April 14, 2023
PubMed

Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients. Varying response rates across tumor types and the need for predictive biomarkers to optimize patient selection to maximize efficacy and minimize toxicities prompted efforts to unravel immune and non-immune factors regulating the responses to ICT. This review highlights the biology of anti-tumor immunity underlying response and resistance to ICT, discusses efforts to address the current challenges with ICT, and outlines strategies to guide the development of subsequent clinical trials and combinatorial efforts with ICT.

Keywords:
CTLA-4ICTPD-1PD-L1combinatorial biomarkerscytotoxic T lymphocyte-associated protein 4immune checkpoint therapyimmune-related adverse eventsirAEsprogrammed cell death protein 1programmed death ligand 1reverse translation

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