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Updated: Aug 2, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment
1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Abstract:
Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or chemotherapy-treated cells) express antigen presentation machinery, present antigens, and interact with T cells and dendritic cells to robustly activate the immune system and promote anti-tumor immunity.
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