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What Is New in Fungal Infections?

Meredith G Parsons1, Daniel J Diekema2

  • 1Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|April 14, 2023
PubMed

Insights

Invasive fungal infections are rising, driven by new pathogens and resistance. Early diagnosis through histopathology is crucial due to limitations in current fungal diagnostic tests.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Invasive fungal infections (IFIs) represent a significant and growing global health challenge.
  • Increasing morbidity and mortality associated with IFIs necessitate updated understanding and management strategies.
  • Emerging trends in IFIs include novel pathogens, broader at-risk populations, and escalating antifungal resistance.

Purpose of the Study:

  • To summarize critical shifts in the epidemiology of invasive fungal infections.
  • To explore the influence of human activity and climate change on IFI trends.
  • To highlight the urgent need for advancements in fungal diagnostics and the role of histopathology.

Main Methods:

  • Review of current literature on invasive fungal infections.
  • Analysis of epidemiological data and emerging trends.
  • Discussion of etiological factors including climate and human impact.

Main Results:

  • Identification of new and emerging fungal pathogens causing IFIs.
  • Expansion of populations susceptible to invasive fungal infections.
  • Evidence of increasing antifungal resistance globally.

Conclusions:

  • Changes in IFI epidemiology are influenced by environmental and anthropogenic factors.
  • Existing diagnostic methods for fungal infections have limitations.
  • Histopathology remains a vital tool for the early and accurate diagnosis of fungal diseases.
Keywords:
emerging pathogensfungal infections

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