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Insulin and disorders of behavioural flexibility

Mairéad Sullivan1, Fernando Fernandez-Aranda2, Lucía Camacho-Barcia3

  • 1Conway Institute of Biomedical and Biomolecular Research, School of Medicine, University College Dublin, Dublin, Ireland.

Neuroscience and Biobehavioral Reviews
|April 14, 2023
PubMed
Summary

Behavioural inflexibility, common in neurodegenerative diseases, is linked to insulin signaling in the brain. Metformin may improve outcomes by targeting these insulin pathways.

Keywords:
AddictionAlzheimer’s diseaseAnorexia NervosaAutism spectrum disorderIGF1InsulinMetforminNeuropsychiatric disordersObesityObsessive-compulsive disorderParkinson’s diseaseType 2 diabetes

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