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Functional carbohydrate-based hydrogels for diabetic wound therapy.

Yu Zhang1, Yingnan Zhu2, Peirong Ma1

  • 1College of Chemistry and Chemical Engineering, Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, People's Republic of China.

Carbohydrate Polymers
|April 14, 2023
PubMed
Summary

Diabetes wounds are a major health challenge. This review highlights carbohydrate-based hydrogels as promising wound dressings, detailing their functionalization for improved diabetes wound healing.

Keywords:
Carbohydrate-based hydrogelsChronic woundDiabeticFunctionalized wound dressingsWound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Diabetology

Background:

  • Diabetes complications include severe, universal wounds with high amputation and mortality rates.
  • Effective treatment and care for diabetic wounds remain a global challenge.
  • Carbohydrate-based hydrogels offer biocompatibility, ease of use, and therapeutic potential for wound dressings.

Purpose of the Study:

  • To systematically review diabetic wound problems and healing mechanisms.
  • To discuss current treatments and wound dressings for diabetic wounds.
  • To explore the application and functionalization of carbohydrate-based hydrogels in diabetic wound management.

Main Methods:

  • Literature review of diabetic wound pathophysiology and treatment strategies.
  • Analysis of common wound dressings and their limitations.
  • Detailed examination of carbohydrate-based hydrogels and their functional modifications (e.g., antibacterial, antioxidant).

Main Results:

  • Diabetic wounds present unique challenges due to impaired healing mechanisms.
  • Carbohydrate-based hydrogels show significant promise as advanced wound dressings.
  • Functionalization of these hydrogels enhances their therapeutic efficacy for diabetic wounds.

Conclusions:

  • Carbohydrate-based hydrogels are ideal candidates for advanced diabetic wound dressings.
  • Functionalized hydrogels offer targeted delivery and enhanced healing properties.
  • Further development in this area could significantly improve patient outcomes for diabetic wounds.